USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: PNPH_HUMAN USC-OGP 2-DE database:  PNPH_HUMAN PNPH_HUMAN General information about the entry View entry in simple text format Entry name PNPH_HUMAN Primary accession number P00491 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Purine nucleoside phosphorylase; Short=PNP; EC=2.4.2.1; AltName: Full=Inosine phosphorylase; AltName: Full=Inosine-guanosine phosphorylase;. Gene name Name=PNP Synonyms=NP Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-7 {PLATELET 4-7} Homo sapiens (Human)   map experimental info   PLATELET_4-7 MAP LOCATIONS: SPOT OGP-0490: pI=6.24; Mw=29572 PLATELET_6-11 {PLATELET 6-11} Homo sapiens (Human)   map experimental info   PLATELET_6-11 MAP LOCATIONS: SPOT OGP-0995: pI=5.99; Mw=27825 SPOT OGP-0997: pI=6.21; Mw=27779 UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1253: pI=6.35; Mw=30714 SPOT OGP-1257: pI=6.46; Mw=30456 SPOT OGP-1263: pI=6.56; Mw=29778 Cross-references UniProtKB/Swiss-Prot P00491; PNPH_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name PNPH_HUMAN Primary accession number P00491 Secondary accession number(s) B2R8S5 D3DS00 Q15160 Q5PZ03 Sequence was last modified on  May 30, 2006 (version 2) Annotations were last modified on  March 15, 2017 (version 189) Name and origin of the protein Description RecName: Full=Purine nucleoside phosphorylase; Short=PNP; EC=2.4.2.1; AltName: Full=Inosine phosphorylase; AltName: Full=Inosine-guanosine phosphorylase; Gene name Name=PNP Synonyms=NP Encoded on Name=PNP; Synonyms=NP Keywords 3D-structure; Acetylation; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Disease mutation; Glycosyltransferase; Phosphoprotein; Polymorphism; Reference proteome; Transferase. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL X00737; CAA25320.1; -; mRNA EMBL M13953; AAA36460.1; -; Genomic_DNA EMBL J02672; AAA36460.1; JOINED; Genomic_DNA EMBL M13951; AAA36460.1; JOINED; Genomic_DNA EMBL M13952; AAA36460.1; JOINED; Genomic_DNA EMBL AY817667; AAV68044.1; -; Genomic_DNA EMBL AK313490; BAG36272.1; -; mRNA EMBL CR407607; CAG28535.1; -; mRNA EMBL CH471078; EAW66458.1; -; Genomic_DNA EMBL CH471078; EAW66459.1; -; Genomic_DNA EMBL BC104206; AAI04207.1; -; mRNA EMBL BC104207; AAI04208.1; -; mRNA EMBL BC106074; AAI06075.1; -; mRNA CCDS CCDS9552.1; -; . PIR A00578; PHHUPN; . RefSeq NP_000261.2; NM_000270.3; . UniGene Hs.75514; -; . PDB 1M73; X-ray; 2.30 A; E=2-289 PDB 1PF7; X-ray; 2.60 A; E=1-289 PDB 1PWY; X-ray; 2.80 A; E=2-289 PDB 1RCT; X-ray; 2.80 A; E=2-289 PDB 1RFG; X-ray; 2.90 A; E=2-289 PDB 1RR6; X-ray; 2.50 A; A=1-289 PDB 1RSZ; X-ray; 2.20 A; A=1-289 PDB 1RT9; X-ray; 2.30 A; A=1-289 PDB 1ULA; X-ray; 2.75 A; A=1-289 PDB 1ULB; X-ray; 2.75 A; A=1-289 PDB 1V2H; X-ray; 2.70 A; E=2-289 PDB 1V3Q; X-ray; 2.80 A; E=2-289 PDB 1V41; X-ray; 2.85 A; E=2-289 PDB 1V45; X-ray; 2.86 A; E=2-289 PDB 1YRY; X-ray; 2.80 A; E=1-289 PDB 2A0W; X-ray; 2.28 A; A=1-289 PDB 2A0X; X-ray; 2.28 A; A=1-289 PDB 2A0Y; X-ray; 2.28 A; A=1-289 PDB 2OC4; X-ray; 2.59 A; A=1-289 PDB 2OC9; X-ray; 2.59 A; A=1-289 PDB 2ON6; X-ray; 2.50 A; A=1-289 PDB 2Q7O; X-ray; 2.90 A; E=1-289 PDB 3BGS; X-ray; 2.10 A; A=1-289 PDB 3D1V; X-ray; 2.70 A; A=1-289 PDB 3GB9; X-ray; 2.30 A; A/B/C=1-289 PDB 3GGS; X-ray; 2.52 A; A/B/C=1-289 PDB 3INY; X-ray; 2.75 A; A=1-289 PDB 3K8O; X-ray; 2.40 A; E/Q/S/T/U/Y=1-289 PDB 3K8Q; X-ray; 2.50 A; A=1-289 PDB 3PHB; X-ray; 2.30 A; E/Q/S/T/U/Y=1-289 PDB 4EAR; X-ray; 1.70 A; A/B/C=1-289 PDB 4EB8; X-ray; 2.30 A; A/B/C=1-289 PDB 4ECE; X-ray; 2.60 A; A/B/C/D/E/F=1-289 PDB 4GKA; X-ray; 2.20 A; A/B/C/D/E/F=1-289 PDB 5ETJ; X-ray; 2.30 A; A/B/C/D/E/F=1-289 PDBsum 1M73; -; . PDBsum 1PF7; -; . PDBsum 1PWY; -; . PDBsum 1RCT; -; . PDBsum 1RFG; -; . PDBsum 1RR6; -; . PDBsum 1RSZ; -; . PDBsum 1RT9; -; . PDBsum 1ULA; -; . PDBsum 1ULB; -; . PDBsum 1V2H; -; . PDBsum 1V3Q; -; . PDBsum 1V41; -; . PDBsum 1V45; -; . PDBsum 1YRY; -; . PDBsum 2A0W; -; . PDBsum 2A0X; -; . PDBsum 2A0Y; -; . PDBsum 2OC4; -; . PDBsum 2OC9; -; . PDBsum 2ON6; -; . PDBsum 2Q7O; -; . PDBsum 3BGS; -; . PDBsum 3D1V; -; . PDBsum 3GB9; -; . PDBsum 3GGS; -; . PDBsum 3INY; -; . PDBsum 3K8O; -; . PDBsum 3K8Q; -; . PDBsum 3PHB; -; . PDBsum 4EAR; -; . PDBsum 4EB8; -; . PDBsum 4ECE; -; . PDBsum 4GKA; -; . PDBsum 5ETJ; -; . ProteinModelPortal P00491; -; . SMR P00491; -; . BioGrid 110921; 38; . DIP DIP-50406N; -; . IntAct P00491; 13; . MINT MINT-1375849; -; . STRING 9606.ENSP00000354532; -; . BindingDB P00491; -; . ChEMBL CHEMBL4338; -; . DrugBank DB03609; 3-Deoxyguanosine; . DrugBank DB01667; 8-azaguanine; . DrugBank DB02796; 9-Deazainosine; . DrugBank DB00242; Cladribine; . DrugBank DB00900; Didanosine; . DrugBank DB02377; Guanine; . DrugBank DB02857; Guanosine; . DrugBank DB04076; Hypoxanthine; . DrugBank DB02230; Immucillin-G; . DrugBank DB04335; Inosine; . DrugBank DB03881; MT-Immucillin-H; . DrugBank DB02568; Peldesine; . DrugBank DB03101; Ribose-1-Phosphate; . GuidetoPHARMACOLOGY 2841; -; . iPTMnet P00491; -; . PhosphoSitePlus P00491; -; . SwissPalm P00491; -; . BioMuta PNP; -; . DMDM 108935929; -; . OGP P00491; -; . EPD P00491; -; . PaxDb P00491; -; . PeptideAtlas P00491; -; . PRIDE P00491; -; . TopDownProteomics P00491; -; . Ensembl ENST00000361505; ENSP00000354532; ENSG00000198805; . GeneID 4860; -; . KEGG hsa:4860; -; . CTD 4860; -; . DisGeNET 4860; -; . GeneCards PNP; -; . HGNC HGNC:7892; PNP; . HPA HPA001625; -; . MalaCards PNP; -; . MIM 164050; gene; . MIM 613179; phenotype; . neXtProt NX_P00491; -; . OpenTargets ENSG00000198805; -; . Orphanet 760; Purine nucleoside phosphorylase deficiency; . PharmGKB PA31694; -; . eggNOG KOG3984; Eukaryota; . eggNOG COG0005; LUCA; . GeneTree ENSGT00550000074740; -; . HOVERGEN HBG002460; -; . InParanoid P00491; -; . KO K03783; -; . OMA MENGYTY; -; . OrthoDB EOG091G0GEE; -; . PhylomeDB P00491; -; . TreeFam TF300049; -; . BioCyc MetaCyc:HS02151-MONOMER; -; . BRENDA 2.4.2.1; 2681; . Reactome R-HSA-6798695; Neutrophil degranulation; . Reactome R-HSA-74217; Purine salvage; . Reactome R-HSA-74259; Purine catabolism; . SABIO-RK P00491; -; . SignaLink P00491; -; . UniPathway UPA00606; -; . ChiTaRS PNP; human; . EvolutionaryTrace P00491; -; . GeneWiki Purine_nucleoside_phosphorylase; -; . GenomeRNAi 4860; -; . PRO PR:P00491; -; . Proteomes UP000005640; Chromosome 14; . Bgee ENSG00000198805; -; . CleanEx HS_NP; -; . ExpressionAtlas P00491; baseline and differential; . Genevisible P00491; HS; . GO GO:0005737; C:cytoplasm; IDA:UniProtKB; . GO GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005576; C:extracellular region; TAS:Reactome; . GO GO:1904813; C:ficolin-1-rich granule lumen; TAS:Reactome; . GO GO:0005622; C:intracellular; IDA:UniProtKB; . GO GO:0005634; C:nucleus; IEA:Ensembl; . GO GO:0034774; C:secretory granule lumen; TAS:Reactome; . GO GO:0008144; F:drug binding; IDA:UniProtKB; . GO GO:0001882; F:nucleoside binding; IDA:UniProtKB; . GO GO:0042301; F:phosphate ion binding; IDA:UniProtKB; . GO GO:0002060; F:purine nucleobase binding; IDA:UniProtKB; . GO GO:0004731; F:purine-nucleoside phosphorylase activity; IDA:UniProtKB; . GO GO:0006955; P:immune response; IMP:UniProtKB; . GO GO:0006148; P:inosine catabolic process; IDA:MGI; . GO GO:0070970; P:interleukin-2 secretion; IMP:UniProtKB; . GO GO:0034356; P:NAD biosynthesis via nicotinamide riboside salvage pathway; IGI:UniProtKB; . GO GO:0043312; P:neutrophil degranulation; TAS:Reactome; . GO GO:0006738; P:nicotinamide riboside catabolic process; IDA:UniProtKB; . GO GO:0006139; P:nucleobase-containing compound metabolic process; IDA:UniProtKB; . GO GO:0046638; P:positive regulation of alpha-beta T cell differentiation; IDA:MGI; . GO GO:0042102; P:positive regulation of T cell proliferation; IDA:MGI; . GO GO:0006195; P:purine nucleotide catabolic process; TAS:Reactome; . GO GO:0043101; P:purine-containing compound salvage; TAS:Reactome; . GO GO:0042493; P:response to drug; IDA:UniProtKB; . GO GO:0034418; P:urate biosynthetic process; IDA:MGI; . Gene3D 3.40.50.1580; -; 1; . InterPro IPR000845; Nucleoside_phosphorylase_d; . InterPro IPR011270; Pur_Nuc_Pase_Ino/Guo-sp; . InterPro IPR011268; Purine_phosphorylase; . InterPro IPR018099; Purine_phosphorylase-2_CS; . PANTHER PTHR11904; PTHR11904; 1; . Pfam PF01048; PNP_UDP_1; 1; . PIRSF PIRSF000477; PurNPase; 1; . SUPFAM SSF53167; SSF53167; 1; . TIGRFAMs TIGR01700; PNPH; 1; . TIGRFAMs TIGR01697; PNPH-PUNA-XAPA; 1; . PROSITE PS01240; PNP_MTAP_2; 1; .

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